Homoveratrylamine → 2-[1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-acetamide

HRID 48656Notes

Reaction equation

HRID 48656 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][C:23]=1[O:24][CH3:25])[CH2:6][CH:7]1[C:16]2[C:11](=[C:12]([O:19][CH3:20])[CH:13]=[CH:14][C:15]=2[O:17][CH3:18])[CH2:10][CH2:9][NH:8]1.Br[CH2:27][C:28](Br)=[O:29].[CH3:31][O:32][C:33]1[CH:34]=[C:35]([CH2:41][CH2:42][NH2:43])[CH:36]=[CH:37][C:38]=1[O:39][CH3:40]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][C:23]=1[O:24][CH3:25])[CH2:6][CH:7]1[C:16]2[C:11](=[C:12]([O:19][CH3:20])[CH:13]=[CH:14][C:15]=2[O:17][CH3:18])[CH2:10][CH2:9][N:8]1[CH2:27][C:28]([NH:43][CH2:42][CH2:41][C:35]1[CH:36]=[CH:37][C:38]([O:39][CH3:40])=[C:33]([O:32][CH3:31])[CH:34]=1)=[O:29]

Participants

4

Reactant 3

HCID 8421HomoveratrylamineHCID 61147Bromoacetyl bromideHCID 227426431-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 227425832-[1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-acetamide

Procedure

prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 3,4-dimethoxyphenylethylamine

Sources & evidence

ORD record
ord-24cdf73c967a42baa00bc09151ea4ce2
Source dataset
uspto-grants-2004_03
Patent number
US06703392B2

Reaction notes

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