Hydrochloric Acid → HCID 19968963, compound

HRID 486611Notes

Reaction equation

HRID 486611 reaction equation
C(OC([NH:8][CH2:9][C:10]([O:12][C:13]1[CH:18]=[CH:17][C:16]([NH:19][C:20]2[C:25]([NH:26][S:27]([C:30]3[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[CH:32][CH:31]=3)(=[O:29])=[O:28])=[CH:24][CH:23]=[CH:22][N:21]=2)=[CH:15][CH:14]=1)=[O:11])=O)(C)(C)C.[ClH:38]>O1CCCC1>[ClH:38].[ClH:38].[NH2:8][CH2:9][C:10]([O:12][C:13]1[CH:14]=[CH:15][C:16]([NH:19][C:20]2[C:25]([NH:26][S:27]([C:30]3[CH:31]=[CH:32][C:33]([O:36][CH3:37])=[CH:34][CH:35]=3)(=[O:28])=[O:29])=[CH:24][CH:23]=[CH:22][N:21]=2)=[CH:17][CH:18]=1)=[O:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15293862HCID 15293862, compound

Product 1

HCID 19968963HCID 19968963, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

272 mg (0.515 mmol) of the compound of Example 60 was added to 10 ml of tetrahydrofuran. 2 ml of concentrated hydrochloric acid was added to the mixture and stirred at room temperature for 3 h. The solvent was distilled off under reduced pressure and the residue was recrystallized from ethanol to obtain 159 mg of the title compound.

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-b8630d321f424443adbc79a0bee8136e
Source dataset
uspto-grants-1994_03
Patent number
US05292758

Reaction notes

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