2-Methoxybenzene-1-sulfonamide → N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-4-pyrimidinyl]-o-methoxybenzenesulfonamide

HRID 486643Notes

Reaction equation

HRID 486643 reaction equation
[CH3:1][O:2][C:3]1[CH:17]=[CH:16][CH:15]=[CH:14][C:4]=1[O:5][C:6]1[C:7](Cl)=[N:8][CH:9]=[N:10][C:11]=1Cl.[CH3:18][O:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[S:26]([NH2:29])(=[O:28])=[O:27]>C(OCC)(=O)C>[OH:2][CH2:3][CH2:4][O:5][C:11]1[N:10]=[CH:9][N:8]=[C:7]([NH:29][S:26]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[O:19][CH3:18])(=[O:28])=[O:27])[C:6]=1[O:5][C:4]1[CH:14]=[CH:15][CH:16]=[CH:17][C:3]=1[O:2][CH3:1]

Participants

4

Reactant 2

HCID 47391442-Methoxybenzene-1-sulfonamideHCID 158191304,6-Dichloro-5-(2-methoxyphenoxy)pyrimidine

Product 1

HCID 19095758N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-4-pyrimidinyl]-o-methoxybenzenesulfonamide

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

By reacting 5-(2-methoxyphenoxy)-4,6-dichloropyrimidine with o-methoxyphenylsulfonamide and thereafter with ethylene glycol Na, there was obtained N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-4-pyrimidinyl]-o-methoxybenzenesulfonamide, m.p. 164°-165° C. (from ethyl acetate).

Sources & evidence

ORD record
ord-d020c6f8d33249919cbcf9822ab9fa85
Source dataset
uspto-grants-1994_03
Patent number
US05292740

Reaction notes

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