Trifluoroacetic acid → HCID 54063270, compound

HRID 486728Notes

Reaction equation

HRID 486728 reaction equation
[C:1]([S:4][CH2:5][C@H:6]1[CH2:10][C@H:9]([C:11]([O:13]C(C)(C)C)=[O:12])[CH2:8][S:7]1)(=[O:3])[CH3:2].FC(F)(F)C(O)=O>C(Cl)Cl>[C:1]([S:4][CH2:5][C@H:6]1[CH2:10][C@H:9]([C:11]([OH:13])=[O:12])[CH2:8][S:7]1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 54295485HCID 54295485, compound

Product 1

HCID 54063270HCID 54063270, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of trans-2-acetylthiomethyl-4-tert-butoxycarbonyltetrahydrothiophene (compound No. 4-1, 130 mg) in methylene chloride (2 ml), trifluoroacetic acid (1 ml) was added and the mixture was stirred for 2 hours at room temperature. The mixture was concentrated in vacuo and the oily residue was purified by a silica gel column chromatography to give 112 mg (quantitative yield) of the titled compound (compound No. 6-1) as white powder.

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. customthe oily residue was purified by a silica gel column chromatography

Sources & evidence

ORD record
ord-7e32bf146caf4157b6ed0e5c0dc2e0af
Source dataset
uspto-grants-1994_03
Patent number
US05292767

Reaction notes

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