Hydrochloric Acid → Cyclopentanesulfonic acid

Temperature

15 °C

A one liter three-neck flask was charged with 300 mL of methylene chloride and 25 grams (245 mmole) of cyclopentyl mercaptan to produce a reaction solution. The reaction solution was chilled to 15° C. in an ice-water bath and followed by the addition of 190 mL of 35% peroxy acetic acid. Said peroxy acetic acid was added over a period of about 3 hours and the reaction solution was maintained at a temperature of about 18°-26° C. After the reaction solution was stirred overnight at room temperature, 100 mL of water and 25 grams of sodium bisulfite were added followed by 2 additional hours of stirring. The reaction solution was then reduced on a rotovap and the pH was adjusted with dilute hydrochloric acid until a white solid precipitate formed. Said precipitate was isolated via filtration and dried in vacuo (50% yield of cyclopentane sulfonic acid).

1. customto produce a reaction solution
2. additionwas added over a period of about 3 hours
3. temperaturethe reaction solution was maintained at a temperature of about 18°-26° C
4. stirringof stirring
5. customformed
6. customwas isolated via filtration

ORD record

ord-55ee458409254b3b89790bdaa887300e

Source dataset

uspto-grants-1994_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05292888