1-Chloro-4-(chloromethyl)benzene → HCID 14677183, compound

HRID 486820Notes

Reaction equation

HRID 486820 reaction equation
[CH2:1]([C:3]1([C:13]2[N:14]=[CH:15][NH:16][CH:17]=2)[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]1=[O:12])[CH3:2].[Cl:18][C:19]1[CH:26]=[CH:25][C:22]([CH2:23]Cl)=[CH:21][CH:20]=1>C(OCC)(=O)C>[CH2:1]([C:3]1([C:13]2[N:14]=[CH:15][N:16]([CH2:23][C:22]3[CH:25]=[CH:26][C:19]([Cl:18])=[CH:20][CH:21]=3)[CH:17]=2)[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]1=[O:12])[CH3:2]

Participants

4

Reactant 2

HCID 77231-Chloro-4-(chloromethyl)benzeneHCID 178435257HCID 178435257, compound

Product 1

HCID 14677183HCID 14677183, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2-ethyl-2-(1H-imidazol-4-yl)-1-indanone and 4-chlorobenzyl chloride were reacted at 60° C. as described in example 5. The yield was 74%. The hydrochloride was prepared in ethyl acetate, m.p. 150°-154° C.

Sources & evidence

ORD record
ord-32261ef04fe047c7905f2407f7aba9c6
Source dataset
uspto-grants-1994_03
Patent number
US05292887

Reaction notes

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