Methyl iodide → HCID 14677199, compound

HRID 486823Notes

Reaction equation

HRID 486823 reaction equation
[CH2:1]([N:8]1[CH:12]=[C:11]([C:13]2([CH2:22][OH:23])[CH2:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH2:14]2)[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:24]I.[H-].[Na+]>O1CCCC1>[CH2:1]([N:8]1[CH:12]=[C:11]([C:13]2([CH2:22][O:23][CH3:24])[CH2:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH2:14]2)[N:10]=[CH:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydride2×HCID 14677197HCID 14677197, compound

Product 1

HCID 14677199HCID 14677199, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The reaction was performed according to example 9c using 1,66 g of [2-(1-benzyl-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-2-yl]methanol (base) and 1,42 g of methyl iodide as starting materials, sodium hydride (0,84 g of a 50% dispersion of NaH in mineral oil) as reagent and dry tetrahydrofuran as solvent.

Sources & evidence

ORD record
ord-79876ffd25ec4680bd31bb989b4a6d17
Source dataset
uspto-grants-1994_03
Patent number
US05292887

Reaction notes

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