HRID48690

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7669

N-Methylbenzylamine

C8H11N

HCID61147

Acetyl bromide, 2-bromo-

C2H2Br2O

结构：COc1ccc(CC2NCCc3cc(OC)c(OC(C)C)cc32)cc1OC

HCID22742720

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(CC2c3cc(OC(C)C)c(OC)cc3CCN2CC(=O)N(C)Cc2ccccc2)cc1OC

HCID22742801

未命名化合物

PROCEDURE

实验过程

prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with N-benzyl-N-methyl-amine

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-dadf5d1a887c4abc8f07e0c73742cc85
来源数据集: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06703392B2
来源说明: uspto-grants-2004_03

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:23]=[CH:24][C:25]=1[O:26][CH3:27])[CH2:6][CH:7]1[C:16]2[C:11](=[CH:12][C:13]([O:21][CH3:22])=[C:14]([O:17][CH:18]([CH3:20])[CH3:19])[CH:15]=2)[CH2:10][CH2:9][NH:8]1.Br[CH2:29][C:30](Br)=[O:31].[CH2:33]([NH:40][CH3:41])[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:23]=[CH:24][C:25]=1[O:26][CH3:27])[CH2:6][CH:7]1[C:16]2[C:11](=[CH:12][C:13]([O:21][CH3:22])=[C:14]([O:17][CH:18]([CH3:20])[CH3:19])[CH:15]=2)[CH2:10][CH2:9][N:8]1[CH2:29][C:30]([N:40]([CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[CH3:41])=[O:31]