Benzene → HCID 19001630, compound

HRID 486942Notes

Reaction equation

HRID 486942 reaction equation
[CH2:1]=[O:2].[ClH:3].[CH:4]([C:7]1[CH:15]=C[C:10]2[O:11][CH2:12]O[C:9]=2[CH:8]=1)([CH3:6])[CH3:5].[CH:16]1C=CC=CC=1>C(OCC)(=O)C>[Cl:3][CH2:16][C:8]1[C:7]([CH:4]([CH3:5])[CH3:6])=[CH:15][C:1]2[O:2][CH2:12][O:11][C:10]=2[CH:9]=1

Participants

6

Reactant 4

HCID 241BenzeneHCID 313Hydrochloric Acid2×HCID 712FormaldehydeHCID 13934185HCID 13934185, compound

Product 1

HCID 19001630HCID 19001630, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Conditions

Temperature
55 °C

Procedure

A mixture comprising 30 g of 37% formalin, 13 ml of concentrated hydrochloric acid and 100 ml of ethyl acetate was heated to 55° C., while passing hydrochloric acid gas through the mixture. A solution of 7.5 g of 5-isopropyl-1,3-benzodioxole in 20 ml of ethyl acetate was dropwise added to the resulting mixture and the obtained mixture was stirred as such for 2.5 hours and cooled, followed by the addition of benzene. The obtained mixture was washed with water, dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated to obtain 10.22 g of the title compound as a crude oil.

Workup

  1. temperaturecooled
  2. washThe obtained mixture was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-b92f7f7a38f5408f8441d37f8d4d0ac4
Source dataset
uspto-grants-1994_03
Patent number
US05292901

Reaction notes

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