Hydrazine hydrate (1:1) → HCID 10999226, compound

HRID 487340Notes

Reaction equation

HRID 487340 reaction equation
C([N:4]1[CH:9]([CH2:10][C:11]#[N:12])[C:8](=[O:13])[NH:7][CH:6]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:5]1=[O:21])(=O)C.O.NN>CN(C)C=O>[CH2:14]([CH:6]1[NH:7][C:8](=[O:13])[CH:9]([CH2:10][C:11]#[N:12])[NH:4][C:5]1=[O:21])[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 19094682HCID 19094682, compound

Product 1

HCID 10999226HCID 10999226, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

5.51 g (0.0193 mol) of 1-acetyl-3-benzyl-6-cyanomethyl-2,5-dioxopiperazine was dissolved in 80 ml of dimethylformamide, 3.86 g of hydrazine monohydrate added and the resulting solution stirred for 3 hours at room temperature. The reaction solution was concentrated under reduced pressure, and the residue washed with water to obtain 3.52 g of 3-benzyl-6-cyanomethyl-2,5-dioxopiperazine. Yield: 72.7%.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. washthe residue washed with water

Sources & evidence

ORD record
ord-0d75443dbd474d29adc5c20570fbba05
Source dataset
uspto-grants-1994_03
Patent number
US05294714

Reaction notes

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