Acetic Acid → HCID 9862738, compound

HRID 487569Notes

Reaction equation

HRID 487569 reaction equation
[CH:1]([CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)[CH2:5][CH2:4]1)=O.[CH2:18]([NH:25][CH3:26])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.C(O)(=O)C.C([BH3-])#N.[Na+]>>[CH2:18]([N:25]([CH2:1][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)[CH2:5][CH2:4]1)[CH3:26])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 7669N-MethylbenzylamineHCID 5003444Sodium cyanoborohydrideHCID 19092260HCID 19092260, compound

Product 1

HCID 9862738HCID 9862738, compound

Procedure

4.0 g (17.1 mmol) of 4-formyl-1-(4-nitrophenyl)piperidine, 2.1 g (17.1 mmol) of N-benzyl-N-methylamine, 1.0 g (17.1 mmol) of acetic acid and 1.1 g (17.1 mmol) of sodium cyanoborohydride were reacted as in Example 1.

Sources & evidence

ORD record
ord-bffe629cd6f0480eaa19f058c25230a6
Source dataset
uspto-grants-1994_03
Patent number
US05296485

Reaction notes

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