Triethylamine → HCID 19092245, compound

HRID 487578Notes

Reaction equation

HRID 487578 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[F:12][C:13]([F:23])([F:22])[C:14]1[CH:15]=[C:16]([CH2:20][NH2:21])[CH:17]=[CH:18][CH:19]=1.C(N(CC)CC)C>C(O)C>[F:12][C:13]([F:22])([F:23])[C:14]1[CH:15]=[C:16]([CH2:20][NH:21][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=[CH:4][N:3]=2)[CH:17]=[CH:18][CH:19]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 759623-(Trifluoromethyl)benzylamineHCID 788644-Chloroquinazoline

Product 1

HCID 19092245HCID 19092245, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1.65 g of 4-chloroquinazoline, 1.5 g of [3-(trifluoromethyl)phenyl]methyl amine, and 1.0 g of triethylamine in 50 ml of ethanol was refluxed for 6 hours. The mixture was then cooled, and washed with water. After removing solvents in vacuo the product was crystallized from a mixture of ethyl acetate and hexane. Yield: 1.0 g. M.P. 145°-146° C.

Workup

  1. temperaturewas refluxed for 6 hours
  2. temperatureThe mixture was then cooled
  3. washwashed with water
  4. customAfter removing solvents in vacuo the product
  5. customwas crystallized from a mixture of ethyl acetate and hexane

Sources & evidence

ORD record
ord-0ef60508583a45ad94a2cc4c9cf15cfe
Source dataset
uspto-grants-1994_03
Patent number
US05296484

Reaction notes

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