Triethylamine → HCID 19092829, compound

HRID 487675Notes

Reaction equation

HRID 487675 reaction equation
[CH2:1]1[CH2:8][CH:7]([NH2:9])[C:5](=[O:6])[NH:4][CH2:3][CH2:2]1.C(N(CC)CC)C.[CH3:17][O:18][C:19]1[CH:20]=[CH:21][C:22]2[O:26][C:25]([C:27](Cl)=[O:28])=[CH:24][C:23]=2[CH:30]=1>ClCCl>[CH3:17][O:18][C:19]1[CH:20]=[CH:21][C:22]2[O:26][C:25]([C:27]([NH:9][CH:7]3[CH2:8][CH2:1][CH2:2][CH2:3][NH:4][C:5]3=[O:6])=[O:28])=[CH:24][C:23]=2[CH:30]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 1024632H-Azepin-2-one, 3-aminohexahydro-HCID 19079635HCID 19079635, compound

Product 1

HCID 19092829HCID 19092829, compoundYield 61.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a being cooled solution of DL-α-amino-ε-caprolactam (0.83 g) and triethylamine (1.1 ml) in dichloromethane (12 ml), a solution of (5-methoxybenzofuran-2-yl)carbonyl chloride (1.37 g) in dichloromethane (5 ml) was added dropwise below 10° C. After being stirred for 3 hours at ambient temperature, the appeared precipitates was collected by filtration to give DL-α-(5-methoxybenzofuran-2-yl)carbonylamino-ε-caprolactam (1.20 g).

Workup

  1. customthe appeared precipitates
  2. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-9290f33e612446ce804db1c469be02cd
Source dataset
uspto-grants-1994_03
Patent number
US05296495

Reaction notes

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