反应详情

A mixture of 17 g of 6-benzyloxy-4-chromanone, 11.3 g of 3-carbomethoxybenzaldehyde, 14.4 g of pyrrolidine, 100 ml of tetrahydrofuran and 300 ml of methanol was stirred at room temperature overnight. The volatiles were evaporated in vacuo to afford the crude product, which was purified by column chromatography on silica gel eluting with dichloromethane. The product fractions were combined and concentrated to an oil which crystallized upon trituration with methanol to give 17.2 g of title product, mp 109°-112° C.

1. customThe volatiles were evaporated in vacuo
2. customto afford the crude product, which
3. customwas purified by column chromatography on silica gel eluting with dichloromethane
4. concentrationconcentrated to an oil which
5. customcrystallized upon trituration with methanol