反应详情

To a solution of 0.600 g of 2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol mono potassium salt in 40 ml of methylene chloride is added 0.218 ml of triethylamine and 0.381 g of trityl chloride. The solution is heated at reflux for 8 hours, cooled and diluted with 30 ml of water. The organic layer is separated and the aqueous layer extracted with methylene chloride. The combined extracts are washed with water, dried with potassium carbonate, filtered and concentrated in vacuo to give 0.785 g of the desired product as a solid. FAB MASS SPEC 665(M+H).

1. temperatureThe solution is heated
2. temperatureat reflux for 8 hours
3. temperaturecooled
4. customThe organic layer is separated
5. extractionthe aqueous layer extracted with methylene chloride
6. washThe combined extracts are washed with water
7. dry with materialdried with potassium carbonate
8. filtrationfiltered
9. concentrationconcentrated in vacuo