反应详情

Dodecylisocyanate (105 mg, 0.49 mmol) was added to a solution of 4-aminomethyl-2-triethylsilylfuran (Compound 2, 70 mg, 0.33 mmol) and triethylamine (69 microliter, 0.49 mmol) in tetrahydrofuran (3 ml) at room temperature. After stirring at room temperature overnight (ca. 16 hours), the reaction mixture was quenched with water. Extraction (ethyl ether) and evaporation of the dried (magnesium sulfate) extracts gave a residue which was purified by flash chromatography on silica using 60% ethyl ether/hexane. Fractions of Rf of about 0.47 on evaporation gave the title urea as an off-white solid.

1. customthe reaction mixture was quenched with water
2. extractionExtraction (ethyl ether) and evaporation of the
3. dry with materialdried (magnesium sulfate)
4. customextracts gave a residue which
5. customwas purified by flash chromatography on silica using 60% ethyl ether/hexane
6. customFractions of Rf of about 0.47 on evaporation