反应详情

Oxalyl chloride (0.59 ml, 6.79 mmol) was added dropwise to a solution of 4-hydroxymethyl-2-triethylsilylfuran (Compound 1, 1.2 g, 5.66 mmol) and triethylamine (0.95 ml, 6.79 mmol) in dichloromethane (10 ml) at 0°. After 10 minutes, the reaction mixture was quenched with ice. Extraction (dichloromethane) and evaporation of the dried (magnesium sulfate) extracts gave an oil, which was purified by flash chromatography on silica using 5% ethyl ether/hexane. Fractions with Rf of about 0.17 gave, after evaporation the title oxalate ester as a colorless oil.

1. customthe reaction mixture was quenched with ice
2. extractionExtraction (dichloromethane) and evaporation of the
3. dry with materialdried (magnesium sulfate)
4. customextracts gave an oil, which
5. customwas purified by flash chromatography on silica using 5% ethyl ether/hexane
6. customFractions with Rf of about 0.17 gave
7. customafter evaporation the title oxalate ester as a colorless oil