Methyl bromoacetate → [2-[(Pyridin-2-yl-methyl)-carbamoyl-methyl]-1-(3,4-dimethoxy-benzyl)-8-methoxy-1,2,3,4-tetrahydro-isoquinolin-5-yloxy]-acetic acid methyl ester

HRID 48824Notes

Reaction equation

HRID 48824 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:31]=[CH:32][C:33]=1[O:34][CH3:35])[CH2:6][CH:7]1[C:16]2[C:11](=[C:12]([OH:19])[CH:13]=[CH:14][C:15]=2[O:17][CH3:18])[CH2:10][CH2:9][N:8]1[CH2:20][C:21]([NH:23]CC1C=CC=CN=1)=[O:22].Br[CH2:37][C:38]([O:40][CH3:41])=[O:39]>>[CH3:41][O:40][C:38](=[O:39])[CH2:37][O:19][C:12]1[CH:13]=[CH:14][C:15]([O:17][CH3:18])=[C:16]2[C:11]=1[CH2:10][CH2:9][N:8]([CH:20]([CH2:6][C:7]1[CH:16]=[CH:11][CH:10]=[CH:9][N:8]=1)[C:21](=[O:22])[NH2:23])[CH:7]2[CH2:6][C:5]1[CH:31]=[CH:32][C:33]([O:34][CH3:35])=[C:3]([O:2][CH3:1])[CH:4]=1

Participants

3

Reactant 2

HCID 60984Methyl bromoacetateHCID 227425532-[1-(3,4-dimethoxy-benzyl)-5-hydroxy-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide

Product 1

HCID 69895401[2-[(Pyridin-2-yl-methyl)-carbamoyl-methyl]-1-(3,4-dimethoxy-benzyl)-8-methoxy-1,2,3,4-tetrahydro-isoquinolin-5-yloxy]-acetic acid methyl ester

Procedure

prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-5-hydroxy-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide with methyl bromoacetate

Sources & evidence

ORD record
ord-2425a704e4e94df3b6a868c72b65deab
Source dataset
uspto-grants-2004_03
Patent number
US06703392B2

Reaction notes

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