Benzyl Bromide → 5-[(12-Phenoxydodecyl)oxy]-2-(phenylmethoxy)benzoic acid methyl ester
Reaction equation
[CH3:1][O:2][C:3](=[O:31])[C:4]1[CH:9]=[C:8]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][O:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:7]=[CH:6][C:5]=1[OH:30].[CH2:32](Br)[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>>[CH3:1][O:2][C:3](=[O:31])[C:4]1[CH:9]=[C:8]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][O:23][C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:7]=[CH:6][C:5]=1[O:30][CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1Participants
3
Procedure
The reaction of 2-hydroxy-5-[(12-phenoxydodecyl)oxy]benzoic acid methyl ester with benzyl bromide as described in Example 102 gave 5-[(12-phenoxydodecyl)oxy]-2-(phenylmethoxy) benzoic acid methyl ester (58% yield, mp 46°-48° ).
Sources & evidence
- ORD record
- ord-d838399133d7425e9f06595ba3614af6
- Source dataset
- uspto-grants-1994_03
- Patent number
- US05298652
Reaction notes
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