反应详情

温度

100 °C

3-Chloropyridazine-6-carboxylic acid (2.5 g) (R. F. Homer, H. Gregory, W. G. Overend and L. F. Wiggins, J. Chem.Soc (1948) 2195-9) was treated with 8M methylamine in ethanol (2.16 ml) and heated at 100° C. in a sealed bomb for 18 hours. The solution was acidified to pH 4 with 5N HCl and the precipitate filtered off to provide title compound (0.58 g). MS (−ve ion chemical ionisation) ml/z 152 ([M-H]−, 100%).

1. filtrationthe precipitate filtered off