Hydrochloric Acid → HCID 22271414, compound

HRID 488460Notes

Reaction equation

HRID 488460 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]([OH:10])=[O:9])=[CH:6][CH:7]=1.[CH3:11][NH2:12].Cl>C(O)C>[CH3:11][NH:12][C:5]1([C:8]([OH:10])=[O:9])[CH:6]=[CH:7][CH:2]=[N:3][NH:4]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6329MethylamineHCID 64157626-chloropyridazine-3-carboxylic Acid

Product 1

HCID 22271414HCID 22271414, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

3-Chloropyridazine-6-carboxylic acid (2.5 g) (R. F. Homer, H. Gregory, W. G. Overend and L. F. Wiggins, J. Chem.Soc (1948) 2195-9) was treated with 8M methylamine in ethanol (2.16 ml) and heated at 100° C. in a sealed bomb for 18 hours. The solution was acidified to pH 4 with 5N HCl and the precipitate filtered off to provide title compound (0.58 g). MS (−ve ion chemical ionisation) ml/z 152 ([M-H]−, 100%).

Workup

  1. filtrationthe precipitate filtered off

Sources & evidence

ORD record
ord-c8d4feb074f7461587197805e9fb7664
Source dataset
uspto-grants-2005_12
Patent number
US06972297B2

Reaction notes

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