(4-Nitrophenyl)acetic acid → HCID 53833682, compound

HRID 488486Notes

Reaction equation

HRID 488486 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11](O)=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH3:14][O:15][C:16]1[CH:17]=[C:18]([CH:21]=[CH:22][C:23]=1[O:24][CH3:25])C=O>N1CCCCC1>[CH3:14][O:15][C:16]1[CH:17]=[CH:18][C:21]([CH:11]=[CH:10][C:7]2[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=2)=[CH:22][C:23]=1[O:24][CH3:25]

Participants

4

Reactant 2

HCID 4661(4-Nitrophenyl)acetic acidHCID 8419Veratraldehyde

Product 1

HCID 53833682HCID 53833682, compoundYield 34%

Reagents, catalysts & solvents 1

HCID 8082PiperidineSolvent

Procedure

The title compound was prepared from p-nitrophenylacetic acid (25.0 g, 0.14 mol), and 3,4-dimethoxybenzaldehyde (21.0 g, 0.14 mol) in piperidine (5 mL) using the procedure described in Example 1, Step A, to yield a yellow solid, 13.4 g (0.047 mol, 34%) of the desired product. mp: 133-134° C.

Sources & evidence

ORD record
ord-fea97c4fa99240cbb5bca671e97e63ef
Source dataset
uspto-grants-2005_12
Patent number
US06972287B1

Reaction notes

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