Sodium Hydroxide → HCID 22269687, compound

HRID 488514Notes

Reaction equation

HRID 488514 reaction equation
C[O:2][C:3](=[O:31])[C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[CH:6][C:5]=1[NH:13][C:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[C:25]([Cl:30])[CH:24]=2)=[CH:16][CH:15]=1.[OH-].[Na+]>CCO.C1COCC1>[Cl:30][C:25]1[CH:24]=[C:23]([CH2:22][CH2:21][CH2:20][C:17]2[CH:16]=[CH:15][C:14]([NH:13][C:5]3[CH:6]=[CH:7][C:8]([N+:10]([O-:12])=[O:11])=[CH:9][C:4]=3[C:3]([OH:31])=[O:2])=[CH:19][CH:18]=2)[CH:28]=[CH:27][C:26]=1[Cl:29]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 53955704HCID 53955704, compound

Product 1

HCID 22269687HCID 22269687, compoundYield 100.9%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

The title compound was 2-{4-[3-(3,4-dichlorophenyl)-propyl]phenylamino}-5-nitrobenzoic acid methyl ester (0.50 g, 1.09 mmol), 2N NaOH (5.0 mL) in EtOH (2 mL) and THF (4 mL) using the procedure described in Example 2. This procedure yielded an orange solid, 0.49 g (1.10 mmol, 100%) of the desired product. mp 153-155° C.

Sources & evidence

ORD record
ord-ddf2572f584a4a7ab60789eb88b2a061
Source dataset
uspto-grants-2005_12
Patent number
US06972287B1

Reaction notes

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