Ethyl 2-hydroxyisobutyrate → 2-Ethoxy-5-(methanesulfonyl)pyridine

Temperature

80 °C

A mixture of ethyl 2-hydroxyisobutyrate (0.41 mL, 3.0 mmol), 2,5-bis(methylsulfonyl)pyridine (J. Heterocycl. Chem. 1985, 22, 1583) (0.70 g, 3.0 mmol) and sodium hydride (60% dispersion in mineral oil, 0.14 g, 3.6 mmol) in 30 mL of anhydrous DMF was heated at 80° C. overnight. The reaction mixture was cooled to room temperature, and was partitioned between saturated aqueous ammonium chloride (200 mL) and ether (200 mL). The organic layer was separated and was washed with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated to dryness, and the residue was purified by flash column chromatography on silica gel eluting with 0 to 80% ethyl acetate in hexane to give the title compound as a 1:1 mixture with 2-ethoxy-5-methylsulfonylpyridine. LC-MS: m/e 288 (M+H)+ (0.70 min).

1. temperatureThe reaction mixture was cooled to room temperature
2. customwas partitioned between saturated aqueous ammonium chloride (200 mL) and ether (200 mL)
3. customThe organic layer was separated
4. washwas washed with water and brine
5. dry with materialdried over anhydrous sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated to dryness
8. customthe residue was purified by flash column chromatography on silica gel eluting with 0 to 80% ethyl acetate in hexane

ORD record

ord-4bb4155b9a4a41fa8dedacfb1d7d4086

Source dataset

uspto-grants-2005_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06972295B2