Hydrochloric Acid → HCID 178479505, compound

HRID 488804Notes

Reaction equation

HRID 488804 reaction equation
O.O.[N:3]1[C:12]2[C:7](=[C:8]([N:13]3[C:17]([CH:18]4[CH2:20][CH2:19]4)=[C:16]([C:21]([NH:23][C:24]([NH2:26])=[NH:25])=[O:22])[CH:15]=[N:14]3)[CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=1.[ClH:27]>O1CCCC1>[OH2:22].[ClH:27].[N:3]1[C:12]2[C:7](=[C:8]([N:13]3[C:17]([CH:18]4[CH2:20][CH2:19]4)=[C:16]([C:21]([NH:23][C:24]([NH2:26])=[NH:25])=[O:22])[CH:15]=[N:14]3)[CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178513082HCID 178513082, compound

Product 1

HCID 178479505HCID 178479505, compoundYield 165%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A suspension of [1-(quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine dihydrate (1.28 g, 3.59 mmol) in tetrahydrofuran (38:4 mL) with vigorous stirring was treated with concentrated hydrochloric acid (0.30 mL, 3.6 mmol). The mixture became homogeneous within one minute and then a solid began to precipitate. The resulting mixture was stirred vigorously for 1 h and filtered. The solid was air-dried to provide 1.11 g (82% yield) of the title compound.

Workup

  1. customto precipitate
  2. stirringThe resulting mixture was stirred vigorously for 1 h
  3. filtrationfiltered
  4. customThe solid was air-dried

Sources & evidence

ORD record
ord-0ec5a63f1c0f4d70bd08d9c461bef1f1
Source dataset
uspto-grants-2005_12
Patent number
US06974813B2

Reaction notes

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