反应详情

温度

70 °C

A mixture of the above nitrile (1.00 g, 4.85 mmol), bromoacetamide (0.67 g, 4.85 mmol), and sodium ethoxide (0.68 g, 10 mmol) in DMF (20 mL) was heated at 70° C. for 1 h before it was allowed to cool to room temperature. The resulting mixture was diluted with water, filtrated and the precipitates washed with ETOH providing the title compound (0.5 g, 39%).

1. temperatureto cool to room temperature
2. filtrationfiltrated
3. washthe precipitates washed with ETOH