Trifluoroacetic acid → HCID 23387352, compound

HRID 488998Notes

Reaction equation

HRID 488998 reaction equation
[C:1]([NH:11][C@H:12]([C:16]([O:18][CH:19]([CH3:32])[C:20]([O:22]CC1C=CC(OC)=CC=1)=[O:21])=[O:17])[CH:13]([CH3:15])[CH3:14])([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2].FC(F)(F)C(O)=O>ClCCl>[C:1]([NH:11][C@H:12]([C:16]([O:18][CH:19]([CH3:32])[C:20]([OH:22])=[O:21])=[O:17])[CH:13]([CH3:14])[CH3:15])([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23387543HCID 23387543, compound

Product 1

HCID 23387352HCID 23387352, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-methoxybenzyl 2-(N-CBZ-L-valyloxy)-propionate (7.8 g, 17.5 mmole) in dichloromethane (100 ml) was added trifluoroacetic acid (10 ml) and the solution was stirred for one hour at room temperature. The solution was evaporated under reduced pressure and the product was isolated by silica gel column chromatography. Yield: 5.0 g

Workup

  1. customThe solution was evaporated under reduced pressure
  2. customthe product was isolated by silica gel column chromatography

Sources & evidence

ORD record
ord-90922862826941529dbf6fb52685a912
Source dataset
uspto-grants-2005_12
Patent number
US06974802B2

Reaction notes

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