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HRID48903

反应详情

EQUATION

反应方程式

HRID 48903 的结构方程式

REACTANTS

反应物

4
结构：O=P([O-])([O-])[O-].[K+].[K+].[K+]
HCID62657

Tripotassium phosphate

K3O4P

结构：CCOC(=O)CC(=O)CCl
HCID69484

Ethyl 4-chloro-3-oxobutanoate

C6H9ClO3

结构：CCCCCC[C@@H](C)O
HCID80080

2-Octanol, (2R)-

C8H18O

结构：NC(=O)C1=CN([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)C=CC1
HCID439153

Adenosine 5'-(trihydrogen diphosphate), P'→5'-ester with 1,4-dihydro-1-.beta.-D-ribofuranosyl-3-pyridinecarboxamide

C21H29N7O14P2

PRODUCTS

生成物

1
结构：CCOC(=O)CC(O)CCl
HCID4377704

ethyl 4-chloro-3-hydroxybutanoate

C6H11ClO3

PROCEDURE

实验过程

100 mM potassium phosphate buffer (pH 6.5), 139.8 mg NADH, 0.06 U (R)-2-octanol dehydrogenase from Candida utilis, and 0.5% 4-chloroacetoacetic acid ethyl ester were reacted overnight at 30° C. The optical purity of the 4-chloro-3-hydroxybutyric acid ethyl ester produced was determined in the same way as Example 32. As a result, 4-chloro-3-hydroxybutyric acid ethyl ester produced by this invention was more than 97% ee of S form.