反应详情

温度

60 °C

To a stirred solution of DL-2-hydroxystearic acid (3.0 g, 10 mmole) in 20 ml dry DMF was added potassium tert-butoxide (1.23 g, 11 mmole) and the mixture was stirred for one hour at 60° C. Benzyl bromide (2.14 g, 12.5 mmole) was added and the mixture was stirred for six hours at 80° C. The mixture was evaporated under reduced pressure and 100 ml ethyl acatate was added. The organic phase was separated and washed four times with water. The organic phase was dried with sodium sulfate and concentrated in vacuo. The product was isolated by silica gel column chromatography. Yield: 3.3 g

1. stirringthe mixture was stirred for six hours at 80° C
2. customThe mixture was evaporated under reduced pressure and 100 ml ethyl acatate
3. additionwas added
4. customThe organic phase was separated
5. washwashed four times with water
6. dry with materialThe organic phase was dried with sodium sulfate
7. concentrationconcentrated in vacuo
8. customThe product was isolated by silica gel column chromatography