Piperidine → 4-(2-chlorophenyl)-6-(piperidin-1-ylmethyl)-2,4-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile;hydrochloride

HRID 489433Notes

Reaction equation

HRID 489433 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[C:13]([C:14]#[N:15])=[C:12]([CH2:16]Br)[NH:11][C:10]2=[N:18][NH:19][CH:20]=[C:9]12.[NH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1>>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[C:13]([C:14]#[N:15])=[C:12]([CH2:16][N:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)[NH:11][C:10]2=[N:18][NH:19][CH:20]=[C:9]12

Participants

3

Reactant 2

HCID 8082PiperidineHCID 178509439HCID 178509439, compound

Product 1

HCID 1784791854-(2-chlorophenyl)-6-(piperidin-1-ylmethyl)-2,4-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile;hydrochloride

Procedure

The title compound was prepared from 4-(2-chlorophenyl)-5-cyano-6-bromomethyl-4,7-dihydro-2H-pyrazolo[3,4-b]pyridine and piperidine in the same manner as in Example 352.

Sources & evidence

ORD record
ord-eafa32cb14e3457f93ea1eb7b9f27fbb
Source dataset
uspto-grants-2005_12
Patent number
US06977262B2

Reaction notes

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