1-Phenylpiperazine → 4-(2-chlorophenyl)-6-[(4-phenylpiperazin-1-yl)methyl]-2,4-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile;trihydrochloride

HRID 489455Notes

Reaction equation

HRID 489455 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[C:13]([C:14]#[N:15])=[C:12]([CH2:16]Br)[NH:11][C:10]2=[N:18][NH:19][CH:20]=[C:9]12.[C:21]1([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[ClH:1].[ClH:1].[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[C:13]([C:14]#[N:15])=[C:12]([CH2:16][N:30]2[CH2:31][CH2:32][N:27]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:28][CH2:29]2)[NH:11][C:10]2=[N:18][NH:19][CH:20]=[C:9]12

Participants

3

Reactant 2

HCID 70961-PhenylpiperazineHCID 178509439HCID 178509439, compound

Product 1

HCID 1784785854-(2-chlorophenyl)-6-[(4-phenylpiperazin-1-yl)methyl]-2,4-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile;trihydrochloride

Procedure

The title compound was prepared from 4-(2-chlorophenyl)-5-cyano-6-bromomethyl-4,7-dihydro-2H-pyrazolo[3,4-b]pyridine and 1-phenylpiperazine in the same manner as in Example 1076.

Sources & evidence

ORD record
ord-9cefe22d687b41d99bc6fbde3da4cc6a
Source dataset
uspto-grants-2005_12
Patent number
US06977262B2

Reaction notes

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