Hydrochloric Acid → 6-amino-1-benzyl-5-nitrosopyrimidine-2,4(1H,3H)-dione

HRID 489472Notes

Reaction equation

HRID 489472 reaction equation
[NH2:1][C:2]1[N:7]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:6](=[O:15])[NH:5][C:4](=[O:16])[CH:3]=1.[N:17]([O-])=[O:18].[Na+].Cl>CN(C)C=O.O>[NH2:1][C:2]1[N:7]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:6](=[O:15])[NH:5][C:4](=[O:16])[C:3]=1[N:17]=[O:18]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 2507466-Amino-1-benzyluracilHCID 23668193Sodium Nitrite

Product 1

HCID 33071146-amino-1-benzyl-5-nitrosopyrimidine-2,4(1H,3H)-dione

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
70 °C

Procedure

To a solution of 6-amino-1-benzyl-1,3-dihydropyrimidine-2,4-dione (2.0 g, 9.2 mmol) in a mixture of 15 ml of N,N-dimethylformamide and 5 ml of water at 90° C. was added sodium nitrite (1.27 g, 69 mmol). To this reaction mixture was added concentrated hydrochloric acid until there was no deepening of color, and the mixture was heated at 70° C. for 1 hour. The solvent was removed under reduced pressure, the residue dissolved in water, and concentrated hydrochloric acid added to produce a pH of 4.0. The precipitate was filtered off, washed with water, and dried under reduced pressure, to provide 6-amino-5-nitroso-1-benzyl-1,3-dihydropyrimidine-2,4-dione, a compound of formula (24).

Workup

  1. customThe solvent was removed under reduced pressure
  2. dissolutionthe residue dissolved in water
  3. additionconcentrated hydrochloric acid added
  4. customto produce a pH of 4.0
  5. filtrationThe precipitate was filtered off
  6. washwashed with water
  7. customdried under reduced pressure

Sources & evidence

ORD record
ord-de0ba5501863471eaafda2a660bcd22d
Source dataset
uspto-grants-2005_12
Patent number
US06977300B2

Reaction notes

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