Acetyl chloride → 1,5-Dihydro-3-methyl-[1,2]diazepino[4,5,6-cd]-indol-6-one

HRID 489530Notes

Reaction equation

HRID 489530 reaction equation
[C:1]1([C:7]2[C:13]3=[CH:14][NH:15][C:16]4[CH:17]=[CH:18][CH:19]=[C:11]([C:12]=43)[C:10](=[O:20])[NH:9][N:8]=2)C=CC=CC=1.N1C2C=CC=C(C(OC)=O)C=2C=C1.C(Cl)(=O)C.[Cl-].[Al+3].[Cl-].[Cl-].O.NN>ClC(Cl)C.CO.Cl>[CH3:1][C:7]1[C:13]2=[CH:14][NH:15][C:16]3[CH:17]=[CH:18][CH:19]=[C:11]([C:12]=32)[C:10](=[O:20])[NH:9][N:8]=1

Participants

9

Reactant 5

HCID 6367Acetyl chlorideHCID 24654Hydrazine hydrate (1:1)HCID 2733668methyl 1H-indole-4-carboxylateHCID 6451240Aluminum(III) ChlorideHCID 1354630341,5-Dihydro-3-phenyl-[1,2]diazepino[4,5,6-cd]-indol-6-one

Product 1

HCID 1355841831,5-Dihydro-3-methyl-[1,2]diazepino[4,5,6-cd]-indol-6-one

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolventHCID 63651,1-DichloroethaneSolvent

Procedure

In a manner similar to that described for compound 28, a solution of methyl indole-4-carboxylate (427 mg, 2.44 mmol) in dichloroethane (7 mL) was treated with acetyl chloride (0.5 mL) and aluminum chloride (130 mg). The intermediate ketone (198 mg, 0.92 mmol) in MeOH (5 mL) and conc. HCl (0.05 mL) was treated, as described, with hydrazine hydrate (0.1 mL). The product precipitated, was collected by filtration and rinsed with ice-cold MeOH to give 1,5-dihydro-3-methyl-[1,2]diazepino[4,5,6-cd]-indol-6-one, 168 mg (92%) as a bright yellow solid: m.p. 335-336° C.; 1H NMR (300 MHz, d6-DMSO) δ 2.17 (s, 3H), 7.19 (t, J=7.8 Hz, 1H), 7.54 (m, 2H), 7.67 (d, J=2.8Hz, 1H), 10.12 (s, 1H), 11.90 (br s, 1H). HRMS (FAB, MH+) Calcd for C11H10N3O: 200.0824. Found: 200.0827. Anal. (C11H9N3O) C, H, N.

Workup

  1. customThe product precipitated
  2. filtrationwas collected by filtration
  3. washrinsed with ice-cold MeOH

Sources & evidence

ORD record
ord-4a3cbb594f9c4b9ca4447a8f162464ec
Source dataset
uspto-grants-2005_12
Patent number
US06977298B2

Reaction notes

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