Hydrochloric Acid → Methanesulfonamide, N-[2-(4-piperidinyl)phenyl]-

HRID 489648Notes

Reaction equation

HRID 489648 reaction equation
[CH3:1][S:2]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH:12]1[CH2:17][CH2:16][NH:15][CH:14](C(OC(C)(C)C)=O)[CH2:13]1)(=[O:4])=[O:3].Cl>CCOC(C)=O>[CH3:1][S:2]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1)(=[O:3])=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69742212Tert-butyl 4-(2-[{methylsulfonyl)amino]phenyl}piperidino-carboxylate

Product 1

HCID 22266255Methanesulfonamide, N-[2-(4-piperidinyl)phenyl]-

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a 25 ml, round-bottomed flask equipped with stirring was added tert-butyl 4-(2-[{methylsulfonyl)amino]phenyl}piperidino-carboxylate (Step d) (610 mg, 1.72 mmol) followed by a saturated soln of HCl in EtOAc (10 mL). The reaction mixture was stirred at RT for 1 h and the title compound (HCl salt) was isolated by filtration as a white solid (460 mg). MS (ESI, pos. ion) m/z: 255 (M+1). Calc'd for C12H19ClN2O2S: 290.81.

Workup

  1. customTo a 25 ml, round-bottomed flask equipped
  2. stirringThe reaction mixture was stirred at RT for 1 h

Sources & evidence

ORD record
ord-e77e0e2a27dd40dc8f9dc0d64fe4506e
Source dataset
uspto-grants-2005_12
Patent number
US06977264B2

Reaction notes

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