反应详情

To a 25 ml, round-bottomed flask equipped with stirring was added tert-butyl 4-(2-[{methylsulfonyl)amino]phenyl}piperidino-carboxylate (Step d) (610 mg, 1.72 mmol) followed by a saturated soln of HCl in EtOAc (10 mL). The reaction mixture was stirred at RT for 1 h and the title compound (HCl salt) was isolated by filtration as a white solid (460 mg). MS (ESI, pos. ion) m/z: 255 (M+1). Calc'd for C12H19ClN2O2S: 290.81.

1. customTo a 25 ml, round-bottomed flask equipped
2. stirringThe reaction mixture was stirred at RT for 1 h