Hydrochloric Acid → HCID 22266192, compound

HRID 489674Notes

Reaction equation

HRID 489674 reaction equation
O[CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH:10]1[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]1.[ClH:23].CC[O:26]C(C)=O>>[ClH:23].[NH:13]1[CH2:14][CH2:15][CH:10]([C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]([OH:26])[CH3:2])[CH2:11][CH2:12]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 69140190HCID 69140190, compound

Product 1

HCID 22266192HCID 22266192, compound

Procedure

The title compound was prepared according to the procedure described in Example 1 (Step e) using tert-butyl 4-(2-(hydroxyethyl)phenyl]piperidinecarboxylate (Step b) (1.22 g, 4.0 mmol) and satd anhydrous HCl in EtOAc (50 mL). The title compound was obtained as a white solid (0.96 g). MS (ESI, pos. ion) m/z: 206 (M+1); MS (ESI, neg. ion) m/z: 204 (M−1). Calc'd for C13H19NO: 205.15.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-908e955cccff4d379f41f20049a727ec
Source dataset
uspto-grants-2005_12
Patent number
US06977264B2

Reaction notes

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