Hydrochloric Acid → HCID 131725246, compound

HRID 489694Notes

Reaction equation

HRID 489694 reaction equation
[CH:1]1[C:13]2[CH:12]([CH2:14][O:15][C:16]([NH:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[CH:25]3[CH2:30][CH2:29][N:28](C(OC(C)(C)C)=O)[CH2:27][CH2:26]3)=[O:17])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[ClH:38]>CCOC(C)=O>[ClH:38].[CH:10]1[C:11]2[CH:12]([CH2:14][O:15][C:16]([NH:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[CH:25]3[CH2:26][CH2:27][NH:28][CH2:29][CH2:30]3)=[O:17])[C:13]3[C:5](=[CH:4][CH:3]=[CH:2][CH:1]=3)[C:6]=2[CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22266252HCID 22266252, compound

Product 1

HCID 131725246HCID 131725246, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was prepared according to the procedure described in Example 16 (Step b) from tert-butyl 4-(2-[(fluoren-9-ylmethoxy)carbonylamino]phenyl)piperidine-carboxylate (Step a) (7.49 g, 15 mmol) and satd anhydrous HCl in EtOAc (50 mL). The title compound was obtained as a white solid (6.51 g). MS (ESI, pos. ion) m/z: 399 (M+1); MS (ESI, neg. ion) m/z: 397 (M−1). Calc'd for C26H27ClN2O2: 398.20.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-40581d19cd9a43ee933173b6f4ef5ccd
Source dataset
uspto-grants-2005_12
Patent number
US06977264B2

Reaction notes

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