反应详情

A mixture of 2-chlorophenyl(2-pyrimidinyl)acetonitile (3.25 g, 0.0142 mol), sodium hydride (60% in mineral oil, 1.07 g, 0.016 mol) and anhydrous tetrahydrofuran is stirred two hours at reflux and cooled to room temperature. Dry air is bubbled into the mixture while stirring three days. The mixture is quenched by dropwise addition of a 3:1 water:methanol mixture and then water. The tetrahydrofuran is removed in vacuo and the aqueous residue filtered to afford the title compound as a brown solid (2.00 g, 64.7%) which is identified by NMR spectral analysis.

1. temperatureat reflux
2. customDry air
3. customis bubbled into the mixture
4. stirringwhile stirring three days
5. customThe mixture is quenched by dropwise addition of a 3:1 water
6. customThe tetrahydrofuran is removed in vacuo
7. filtrationthe aqueous residue filtered