反应详情

温度

70 °C

To a solution of methyl 6-amino-5-iodo-2-(methyloxy)-3-pyridinecarboxylate (1.4 g, 4.54 mmol) in methanol (30 ml), 1M aqueous lithium hydroxide (9 ml, 9 mmol) was added and the mixture was heated at 70° C. for 2 h. After cooling to room temperature, the mixture was concentrated in vacuo to give a solid. The residual solid was dissolved in water (50 ml) and acidified (pH=5) by addition of 2N aqueous hydrochloric acid. The resultant solid was collected by filtration, washed with water and dried in vacuo under 60° C. to give 1.3 g (92%) of the title compound.

1. temperatureAfter cooling to room temperature
2. concentrationthe mixture was concentrated in vacuo
3. customto give a solid
4. filtrationThe resultant solid was collected by filtration
5. washwashed with water
6. customdried in vacuo under 60° C.