反应详情

9 g (90.75 mmol) of 4-methylpiperidine and 13.9 ml (100 mol) of triethylamine were dissolved in 100 ml of THC and, at −30° C., 54.9 ml (100 mmol) of phosgene in toluene (20 percent) were added, and the mixture was stirred for 2.5 h, during which it warmed to room temperature. The reaction mixture was concentrated, the residue was mixed with methylene chloride and filtered off, and the filtrate was concentrated. The crude product (12.7 g) was reacted without further purification.

1. concentrationThe reaction mixture was concentrated
2. additionthe residue was mixed with methylene chloride
3. filtrationfiltered off
4. concentrationthe filtrate was concentrated
5. customThe crude product (12.7 g) was reacted without further purification