4-Carbobenzyloxy-1-(5,6-dichloro-2-nitrophenyl)piperazine-2-carboxylic acid → 3-Carbobenzyloxy-9,10-Dichloro-2,3,4,4a-Tetrahydro-1H-Pyrazino[1,2-a]Quinoxalin-5(6H)-One
Reaction equation
[C:1]([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[C:22]([Cl:23])=[C:21]([Cl:24])[CH:20]=[CH:19][C:18]=2[N+:25]([O-])=O)[CH:13]([C:28]([OH:30])=O)[CH2:12]1)([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2]>[Fe]>[C:1]([N:11]1[CH2:16][CH2:15][N:14]2[C:17]3[C:18]([NH:25][C:28](=[O:30])[CH:13]2[CH2:12]1)=[CH:19][CH:20]=[C:21]([Cl:24])[C:22]=3[Cl:23])([O:3][CH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1)=[O:2]Participants
3
Procedure
By the same procedure described for Example 7 B, from 0.75 g of 4-carbobenzyloxy-1-(5,6-dichloro-2-nitrophenyl)piperazine-2-carboxylic acid and 0.28 g of iron powder, there was obtained 0.34 g (49%) of the desired product as a brown solid.
Sources & evidence
- ORD record
- ord-1390c26cb3bd43e8aa6540a4f555b7d0
- Source dataset
- uspto-grants-2004_03
- Patent number
- US06706714B2
Reaction notes
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