反应详情

To a solution of 4-azido-1-benzyl-pyrrolidine-2-carboxylic acid methyl ester (9) in THF under N2 is added triphenylphosphine and water. The mixture is refluxed with stirring for about 6 h. After removal of THF, the residue is dissolved in Et2O, treated with HCl, stirred for 5 min, and extracted with Et2O. The aqueous solution is then treated with NaHCO3 and extracted, dried and concentrated to afford product 4-amino-1-benzyl-pyrrolidine-2-carboxylic acid methyl ester (10).

1. temperatureThe mixture is refluxed
2. customAfter removal of THF
3. dissolutionthe residue is dissolved in Et2O
4. additiontreated with HCl
5. stirringstirred for 5 min
6. extractionextracted with Et2O
7. additionThe aqueous solution is then treated with NaHCO3
8. extractionextracted
9. customdried
10. concentrationconcentrated