Lithium Hydroxide → HCID 67548074, compound

HRID 490588Notes

Reaction equation

HRID 490588 reaction equation
C[O:2][C:3]([CH:5]1[CH2:9][CH:8]([NH:10][C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:7][N:6]1[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:4].[Li+].[OH-]>C1COCC1.O>[CH2:18]([N:6]1[CH2:7][CH:8]([NH:10][C:11]([O:13][C:14]([CH3:16])([CH3:17])[CH3:15])=[O:12])[CH2:9][CH:5]1[C:3]([OH:4])=[O:2])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 67546663HCID 67546663, compound

Product 1

HCID 67548074HCID 67548074, compound

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

1-Benzyl-4-tert-butoxycarbonylamino-pyrrolidine-2-carboxylic methyl ester and LiOH are dissolved in THF/H2O, and the resulting mixture is stirred for about 5 hours at room temperature. After removal of the solvent, the PH is adjusted to 6-7. The solid is collected and dried to afford 1-benzyl-4-tert-butoxycarbonylamino-pyrrolidine-2-carboxylic acid (40).

Workup

  1. customAfter removal of the solvent
  2. customThe solid is collected
  3. customdried

Sources & evidence

ORD record
ord-2f56071fa41c4c2b91a3f25a5fcb2ed5
Source dataset
uspto-grants-2009_05
Patent number
US07528136B2

Reaction notes

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