Hydrochloric Acid → HCID 67529443, compound

HRID 490911Notes

Reaction equation

HRID 490911 reaction equation
[ClH:1].[CH2:2]([N:4]1[C:8]2=[N:9][CH:10]=[C:11]([C:20]3[O:24][N:23]=[C:22]([CH2:25][CH:26]4[CH2:31][CH2:30][N:29](C(OC(C)(C)C)=O)[CH2:28][CH2:27]4)[N:21]=3)[C:12]([NH:13][CH:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)=[C:7]2[CH:6]=[N:5]1)[CH3:3]>O1CCOCC1>[ClH:1].[CH2:2]([N:4]1[C:8]2[N:9]=[CH:10][C:11]([C:20]3[O:24][N:23]=[C:22]([CH2:25][CH:26]4[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]4)[N:21]=3)=[C:12]([NH:13][CH:14]3[CH2:15][CH2:16][O:17][CH2:18][CH2:19]3)[C:7]=2[CH:6]=[N:5]1)[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57675199HCID 57675199, compound

Product 1

HCID 67529443HCID 67529443, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
20 °C

Procedure

A solution of hydrogen chloride in dioxane (1 ml) was added to Intermediate 124 (0.052 g, 0.1 mmol) and the reaction mixture stirred at 20° C. for 2 hours. The solution was evaporated in vacuo to afford Intermediate 125 as a yellow solid (0.047 g). LCMS showed MH+=412; TRET=2.21 min.

Workup

  1. customThe solution was evaporated in vacuo

Sources & evidence

ORD record
ord-b695aa737e9442999043927f61e55009
Source dataset
uspto-grants-2009_05
Patent number
US07528148B2

Reaction notes

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