Lithium Hydroxide → Hydrogen Peroxide

HRID 491004Notes

Reaction equation

C(C1CCCC1=[O:11])CCCC.[OH-:12].[Li+].[C:14]([O:18][CH2:19][CH3:20])(=[O:17])[CH2:15][CH3:16]>>[OH:12][OH:11].[C:14]([O:18][CH2:19][CH3:20])(=[O:17])[CH2:15][CH3:16]

Participants

Reactant 3

HCID 3939Lithium Hydroxide

HCID 7749Ethyl Propionate2×

HCID 209592-Pentylcyclopentan-1-one

Product 2

HCID 784Hydrogen PeroxideYield 70%

HCID 7749Ethyl Propionate

Conditions

Temperature: 100 °C

Procedure

In a three-necked 250 ml flask equipped with a magnetic stirrer and a reflux condenser were introduced 31 g of 2-pentyl cyclopentanone (0.2 mole), 31 g of anhydrous ethyl propionate, and 0.048 g (1 mol %) of anhydrous lithium hydroxide. The mixture was brought to reflux at ca. 100° C. Then 57.5 g (0.22 mole) of an anhydrous 13% w/w hydrogen peroxide solution in ethyl propionate, obtained from extraction of a 70% aqueous H2O2 solution by ethyl propionate, were slowly added over 4 h in the reactor while maintaining the reflux 2 h after the end of the introduction. The reaction mixture was then washed with 10% water to remove the non converted H202, and finally distilled to recover the solvent.

Workup

customIn a three-necked 250 ml flask equipped with a magnetic stirrer and a reflux condenser

Sources & evidence

ORD record: ord-49e5d0f58fc64b419aca1d2c022e69e8
Source dataset: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07528268B2

Reaction notes

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