Piperidine → HCID 69436130, compound

HRID 49108Notes

Reaction equation

HRID 49108 reaction equation
[CH3:1][NH:2][S:3]([C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10](=[O:15])[CH2:9]2)(=[O:5])=[O:4].[CH3:16][O:17][C:18]1[CH:26]=[CH:25][CH:24]=[C:23]2[C:19]=1[CH:20]=[C:21]([CH:27]=O)[NH:22]2.N1CCCCC1>C(O)C>[CH3:1][NH:2][S:3]([C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10](=[O:15])[C:9]2=[CH:27][C:21]1[NH:22][C:23]2[C:19]([CH:20]=1)=[C:18]([O:17][CH3:16])[CH:26]=[CH:25][CH:24]=2)(=[O:5])=[O:4]

Participants

5

Reactant 3

HCID 8082PiperidineHCID 10176909N-methyl-2-oxoindoline-5-sulfonamideHCID 106788384-methoxy-1H-indole-2-carbaldehyde

Product 1

HCID 69436130HCID 69436130, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid methylamide (194 mg, 0.86 mmol), 4-methoxy-1H-indole-2-carbaldehyde (150 mg, 0.86 mmol) and piperidine (36 mg, 0.43 mmol) in ethanol (0.2M) was stirred at room temperature for a total of 5 days. The reaction was concentrated to ¼ of its volume and the precipitate was collected by vacuum filtration to give the title compound as a pale orangish-red solid.

Workup

  1. concentrationThe reaction was concentrated
  2. filtrationthe precipitate was collected by vacuum filtration

Sources & evidence

ORD record
ord-04e993e7259643b294fbed62d7615853
Source dataset
uspto-grants-2004_03
Patent number
US06706709B2

Reaction notes

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