HRID491165

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3939

Lithium hydroxide anhydrous

HLiO

结构：COC(=O)[C@@H](Cc1cc(C)c(OCc2ccccc2)c(C)c1)OC(=O)N1CCC(n2c(=O)[nH]c3c4ccccc4ncc32)CC1

HCID68676084

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(C[C@@H](OC(=O)N2CCC(n3c(=O)[nH]c4c5ccccc5ncc43)CC2)C(=O)O)cc(C)c1OCc1ccccc1

HCID68675784

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

A solution of 250 mg (10.42 mmol) LiOH in 10 mL water was added to a solution of 2.50 g (4.11 mmol) (R)-2-(4-benzyloxy-3,5-dimethyl-phenyl)-1-methoxycarbonyl-ethyl 4-(2-oxo-1,2-dihydro-imidazo[4,5-c]quinolin-3-yl)-piperidine-1-carboxylate in 20 mL THF and the reaction mixture was stirred for 2 h at RT. The organic solvent was removed i.vac., the aqueous residue was acidified with 2 M HCL and combined with EtOAc/DCM (2:1). The precipitate formed was filtered off and dried.

WORKUP

后处理

customThe organic solvent was removed i.vac
customThe precipitate formed
filtrationwas filtered off
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1904b79f449248a4816ac313d5ec2859
来源数据集: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07528129B2
来源说明: uspto-grants-2009_05

反应 SMILES

[Li+].[OH-].[O:3]=[C:4]1[N:16]([CH:17]2[CH2:22][CH2:21][N:20]([C:23]([O:25][C@@H:26]([C:44]([O:46]C)=[O:45])[CH2:27][C:28]3[CH:33]=[C:32]([CH3:34])[C:31]([O:35][CH2:36][C:37]4[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=4)=[C:30]([CH3:43])[CH:29]=3)=[O:24])[CH2:19][CH2:18]2)[C:7]2[CH:8]=[N:9][C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=3[C:6]=2[NH:5]1>O.C1COCC1>[O:3]=[C:4]1[N:16]([CH:17]2[CH2:18][CH2:19][N:20]([C:23]([O:25][C@@H:26]([C:44]([OH:46])=[O:45])[CH2:27][C:28]3[CH:33]=[C:32]([CH3:34])[C:31]([O:35][CH2:36][C:37]4[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=4)=[C:30]([CH3:43])[CH:29]=3)=[O:24])[CH2:21][CH2:22]2)[C:7]2[CH:8]=[N:9][C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=3[C:6]=2[NH:5]1