O-Methylhydroxylamine hydrochloride → HCID 76590131, compound

HRID 491262Notes

Reaction equation

HRID 491262 reaction equation
[Cl:1][C:2]1[C:10]2[C:9]([NH:11][CH2:12][CH2:13][C:14]3[CH:28]=[CH:27][C:17]([O:18][C:19]4[N:24]=[CH:23][C:22]([CH:25]=O)=[CH:21][CH:20]=4)=[CH:16][CH:15]=3)=[N:8][CH:7]=[N:6][C:5]=2[S:4][CH:3]=1.Cl.[O:30]([NH2:32])[CH3:31]>C(O)C.O>[CH3:31][O:30][N:32]=[CH:25][C:22]1[CH:23]=[N:24][C:19]([O:18][C:17]2[CH:16]=[CH:15][C:14]([CH2:13][CH2:12][NH:11][C:9]3[C:10]4[C:2]([Cl:1])=[CH:3][S:4][C:5]=4[N:6]=[CH:7][N:8]=3)=[CH:28][CH:27]=2)=[CH:20][CH:21]=1

Participants

5

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 57677122HCID 57677122, compound

Product 1

HCID 76590131HCID 76590131, compoundYield 77%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of 6-{4-[2-(5-Chlorothieno[2,3-d]pyrimidin-4-ylamino)ethyl]phenoxy}pyridine-3-carbaldehyde (0.2 g, 0.5 mmol) and methoxylamine hydrochloride (0.2 g, 2.5 mmol) in ethanol (10 mL) was heated at reflux for 1 hour. After cooling, the reaction was diluted with water and the solid collected by filtration and air dried affording product, 0.17 g, 0.4 mmol, 77 percent yield.

Workup

  1. temperatureat reflux for 1 hour
  2. temperatureAfter cooling
  3. filtrationthe solid collected by filtration and air
  4. customdried
  5. customaffording product, 0.17 g, 0.4 mmol, 77 percent yield

Sources & evidence

ORD record
ord-19fddc9a53e944fb98e37ec52469b909
Source dataset
uspto-grants-2009_05
Patent number
US07531482B2

Reaction notes

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