4'-Methoxy-3-nitro-biphenyl-4-malonate → 4'-Methoxy-3-nitrobiphenyl-4-acetic acid

HRID 49132Notes

Reaction equation

HRID 49132 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([CH:15](C([O-])=O)[C:16]([O-:18])=[O:17])=[C:11]([N+:22]([O-:24])=[O:23])[CH:10]=2)=[CH:5][CH:4]=1>Cl>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:14]=[CH:13][C:12]([CH2:15][C:16]([OH:18])=[O:17])=[C:11]([N+:22]([O-:24])=[O:23])[CH:10]=2)=[CH:7][CH:8]=1

Participants

3

Reactant 1

HCID 219257634'-Methoxy-3-nitro-biphenyl-4-malonate

Product 1

HCID 104935034'-Methoxy-3-nitrobiphenyl-4-acetic acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Crude 4′-methoxy-3-nitro-biphenyl-4-malonate was heated at 100° C. in 60 mL of 6N hydrochloric acid for 15 hours and cooled. The precipitate was collected by filtration, washed with water and hexane, and dried to give 7.2 g of crude 4′-methoxy-3-nitrobiphenyl-4-acetic acid as a light tan solid.

Workup

  1. temperaturecooled
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water and hexane
  4. customdried

Sources & evidence

ORD record
ord-f88c80a779da411fabf953662200c5dd
Source dataset
uspto-grants-2004_03
Patent number
US06706709B2

Reaction notes

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