反应详情

A 100 mL round bottom flask equipped with magnetic stir bar was charged with 5.7 g methyl. 2-methyl-4-trimethylsilyloxybenzoate and 2.0 g LiOH in 40 mL methanol and 10 mL water. After 2 hours at reflux the reaction was poured into 10 mL concentrated HCl and then 100 g ice. Extraction with ethyl acetate followed by concentration in vacuo gave a crude solid (70:30) product:starting material. Flash Chromatography using 50-50 ethyl acetate/hexanes as an eluent gave 1.15 g 2-methyl-4-hydroxybenzoic acid, m/e=193(M+H).

1. customA 100 mL round bottom flask equipped with magnetic stir bar
2. additionwas charged with 5.7 g methyl
3. temperatureAfter 2 hours at reflux the reaction
4. extractionExtraction with ethyl acetate
5. concentrationfollowed by concentration in vacuo
6. customgave a crude solid (70:30) product