Hydrochloric Acid → HCID 17973627, compound

HRID 491478Notes

Reaction equation

HRID 491478 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][C:10]2([CH2:17][CH2:16][N:15]([C:18](=[O:20])[CH3:19])[CH2:14][CH2:13]2)[CH2:9]1)=O)(C)(C)C.[ClH:21]>C(OCC)(=O)C>[ClH:21].[CH2:9]1[C:10]2([CH2:13][CH2:14][N:15]([C:18](=[O:20])[CH3:19])[CH2:16][CH2:17]2)[CH2:11][CH2:12][NH:8]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68981965HCID 68981965, compound

Product 1

HCID 17973627HCID 17973627, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a solution of 8-acetyl-2,8-diaza-spiro[4.5]decane-2-carboxylic acid tert-butyl ester (1.34 g) in ethyl acetate (10 ml), a 1 M ethyl acetate solution of HCl (20 ml). After stirring for 2 h at room temperature, the reaction mixture is evaporated down to give 1-(2,8-diaza-spiro[4.5]dec-8-yl)-ethanone hydrochloride as a solid.

Workup

  1. customthe reaction mixture is evaporated down

Sources & evidence

ORD record
ord-fcf4386a5d5d4a5a81803161063c34d7
Source dataset
uspto-grants-2009_05
Patent number
US07531546B2

Reaction notes

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