反应详情

温度

80 °C

Ethyl 6-(2,3-dichlorobenzyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylate (400 mg, 1.1 mmol) obtained in Step 3 was suspended in dimethylformamide (DMF; 8 ml), 2-bromoethyl acetate (152 μl, 1.4 mmol) and potassium carbonate (440 mg, 3.2 mmol) were added, and the mixture was stirred with heating at 80° C. 2-Bromoethyl acetate (152 μl, 1.4 mmol) was added twice on the way, and the mixture was stirred with heating at 80° C. for 1.5 hr in total. After allowing to cool, saturated aqueous ammonium chloride was added to the reaction mixture, and the precipitated solid was collected by filtration, washed with water, and vacuum dried to give the object product (468 mg, yield 95%) as a white solid.

1. stirringthe mixture was stirred
2. temperaturewith heating at 80° C. for 1.5 hr in total
3. temperatureto cool
4. filtrationthe precipitated solid was collected by filtration
5. washwashed with water, and vacuum
6. customdried